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Am J Physiol Regul Integr Comp Physiol 253: R167-R171, 1987;
0363-6119/87 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 253, Issue 1 167-R171, Copyright © 1987 by American Physiological Society

ARTICLES

High-affinity substance P binding sites in rat esophagus plexus submucosus

C. J. Wiedermann, K. Sertl and C. B. Pert

Substance P receptors were investigated in rat esophagus using 125I-Bolton-Hunter substance P as a labeling probe. Autoradiographic studies show that esophageal submucosa contains clusters of high-affinity substance P binding sites [maximum binding (Bmax) 4.2 +/- 0.28 fmol/mg protein; dissociation constant (Kd) 0.1 +/- 0.01 X 10(9) M]. The receptor distribution pattern is typical for submucous neurons. These data suggest that substance P may act as a neurotransmitter in rat esophagus.




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