AJP - Regulatory, Integrative and Comparative Physiology, Vol 252, Issue 5 925-R929, Copyright © 1987 by American Physiological Society

ARTICLES

Cardiac control of salt appetite

E. Toth, J. Stelfox and S. Kaufman

Inflation of a balloon for 2 h at the superior vena caval-right atrial junction of the rat reduced the salt intake of animals that had been sodium and water depleted by peritoneal dialysis with hyperoncotic colloid. After the balloons were deflated, the experimental group drank more than the control group so that the total sodium intake of the two groups was the same. Thus stimulated increased venous return to the heart attenuates salt appetite. Since this phenomenon might be secondary to a reflex reduction in plasma renin activity, the experiment was repeated using a model of salt appetite in which the renin-angiotensin system is known to be suppressed, namely the deoxycorticosterone acetate-treated rat. Salt intake was again significantly reduced by inflation of the right atrial balloon. It is concluded that pathways exist, independent of the renin-angiotensin system, whereby information obtained from the cardiac volume receptors regarding the state of filling of the vasculature may be used to regulate salt intake.

This article has been cited by other articles:

				J. I. F. De Gobbi, J. V. Menani, T. G. Beltz, R. F. Johnson, R. L. Thunhorst, and A. K. Johnson Right atrial stretch alters fore- and hind-brain expression of c-fos and inhibits the rapid onset of salt appetite J. Physiol., August 1, 2008; 586(15): 3719 - 3729. [Abstract] [Full Text] [PDF]

				J. C. Geerling and A. D. Loewy Central regulation of sodium appetite Exp Physiol, February 1, 2008; 93(2): 177 - 209. [Abstract] [Full Text] [PDF]

				R. L. Thunhorst, T. G. Beltz, and A. K. Johnson Glucocorticoids increase salt appetite by promoting water and sodium excretion Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1444 - R1451. [Abstract] [Full Text] [PDF]

				R. L. Thunhorst and A. K. Johnson Effects of hypotension and fluid depletion on central angiotensin-induced thirst and salt appetite Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2001; 281(5): R1726 - R1733. [Abstract] [Full Text] [PDF]

				G. H. M. Schoorlemmer, A. K. Johnson, and R. L. Thunhorst Circulating angiotensin II mediates sodium appetite in adrenalectomized rats Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2001; 281(3): R723 - R729. [Abstract] [Full Text] [PDF]

				D. M. Roesch, R. E. Blackburn-Munro, and J. G. Verbalis Mineralocorticoid treatment attenuates activation of oxytocinergic and vasopressinergic neurons by icv ANG II Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2001; 280(6): R1853 - R1864. [Abstract] [Full Text] [PDF]

				D. A. Fitts, E. M. Starbuck, and A. Ruhf Circumventricular organs and ANG II-induced salt appetite: blood pressure and connectivity Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2000; 279(6): R2277 - R2286. [Abstract] [Full Text] [PDF]

				J. V. Menani and A. K. Johnson Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1998; 275(5): R1431 - R1437. [Abstract] [Full Text] [PDF]

				J. V. Menani, L. A. De Luca Jr., and A. K. Johnson Lateral parabrachial nucleus serotonergic mechanisms and salt appetite induced by sodium depletion Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1998; 274(2): R555 - R560. [Abstract] [Full Text] [PDF]