AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 252: R1019-R1023, 1987;
0363-6119/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Koepke, J. P.
Right arrow Articles by DiBona, G. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Koepke, J. P.
Right arrow Articles by DiBona, G. F.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 252, Issue 5 1019-R1023, Copyright © 1987 by American Physiological Society

ARTICLES

Renal nerves mediate blunted natriuresis to atrial natriuretic peptide in cirrhotic rats

J. P. Koepke, S. Jones and G. F. DiBona

The diuretic and natriuretic responses to atrial natriuretic peptide in conscious rats with cirrhosis (chronic bile duct ligation) were examined. Cirrhotic rats had sodium retention, ascites, and elevated liver weights. In conscious control rats, atrial natriuretic peptide increased urine flow rate and urinary sodium excretion. In conscious cirrhotic rats, atrial natriuretic peptide had no effect on urine flow rate or urinary sodium excretion. Renal denervation reversed the blunted diuretic and natriuretic responses to atrial natriuretic peptide in cirrhotic rats. Renal sympathetic nerve activity increased in conscious cirrhotic rats during infusion of atrial natriuretic peptide but decreased in conscious control rats. Inhibition of the renin-angiotensin system with captopril had no effect on the diuretic or natriuretic responses to atrial natriuretic peptide in conscious control or cirrhotic rats. Mean arterial pressure, glomerular filtration rate, and renal plasma flow were affected similarly by atrial natriuretic peptide in control and cirrhotic rats. Increased renal sympathetic nerve activity, but not angiotensin II, mediates the blunted diuretic and natriuretic responses to atrial natriuretic peptide in conscious cirrhotic rats.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
M.-C. Ma, H.-S. Huang, C.-T. Chien, M.-S. Wu, and C.-F. Chen
Temporal decrease in renal sensory responses in rats after chronic ligation of the bile duct
Am J Physiol Renal Physiol, July 1, 2002; 283(1): F164 - F172.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
J. C. Casar, A. Valdivieso, J. A. Bravo, C. Chacón, and M. P. Boric
Reduced Natriuresis After Oral Sodium Load in Cholestatic Rats: Role of Compartment Volumes and ANP
Experimental Biology and Medicine, October 1, 2000; 225(1): 23 - 31.
[Abstract] [Full Text]

Home page
 Physiol. GenomicsHome page
L. G. MELO, M. E. STEINHELPER, S. C. PANG, Y. TSE, and U. ACKERMANN
ANP in regulation of arterial pressure and fluid-electrolyte balance: lessons from genetic mouse models
Physiol Genomics, June 29, 2000; 3(1): 45 - 58.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. D. Voigt, S. Y. Jones, and G. F. DiBona
Role of angiotensin in renal sympathetic activation in cirrhotic rats
Am J Physiol Renal Physiol, August 1, 1999; 277(2): F245 - F250.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online