AJP - Regulatory, Integrative and Comparative Physiology, Vol 252, Issue 2 423-R427, Copyright © 1987 by American Physiological Society
Atrial natriuretic peptide blocks renin response to renal hypotension
D. A. Scheuer, T. N. Thrasher, E. W. Quillen Jr, C. H. Metzler and D. J. Ramsay
We have reported that the renin response to systemic hypotension is
inhibited in the presence of elevated atrial pressure and that elevations
in atrial pressure of similar or larger magnitude cause graded increases in
plasma atrial natriuretic peptide (ANP). Therefore we tested the hypothesis
that comparable increments in plasma ANP can inhibit renal
hypotension-induced increases in plasma renin activity (PRA) in conscious
dogs. Renal perfusion pressure was controlled using cuffs implanted around
the abdominal aorta just above the renal arteries. Reducing renal perfusion
pressure by 10 or 30% of control caused graded increases in PRA (P less
than 0.01). Infusion of 1-28 rat ANP (5 ng X kg-1 X min-1), which increased
plasma ANP by 34.8 +/- 7.5 (SE) pg/ml, eliminated increases in PRA in
response to a 10% reduction in renal perfusion pressure and markedly
inhibited the response to a 30% pressure reduction (P less than 0.01).
These results indicate that increments in plasma ANP which reproduce
endogenous release inhibit renal hypotension-induced stimulation of PRA.
Furthermore, the results provide an explanation for the inhibition of the
renin response to renal hypotension during elevated atrial pressure.
