AJP - Regu AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 251: R749-R754, 1986;
0363-6119/86 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Turlejska, E.
Right arrow Articles by Baker, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Turlejska, E.
Right arrow Articles by Baker, M. A.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 251, Issue 4 749-R754, Copyright © 1986 by American Physiological Society

ARTICLES

Elevated CSF osmolality inhibits thermoregulatory heat loss responses

E. Turlejska and M. A. Baker

The effect of intracerebroventricular (icv) infusions of hypertonic NaCl or sucrose on thermoregulatory responses to heat was studied in conscious rabbits to test the idea that brain osmoreceptors are involved in the inhibition of evaporative heat loss and elevation of body temperature in dehydrated mammals at high ambient temperature (Ta). In rabbits hydrated ad lib and resting at a Ta of 33 degrees C, icv infusion (3.4 microliter/min) of hypertonic (1,500 mosm) NaCl or sucrose in artificial cerebrospinal fluid (ACSF) produced a significant reduction in respiratory frequency (f) and in ear skin temperature (Te) and a rise in brain temperature (preoptic area, Tpoa). icv infusion of ACSF alone or ACSF + NaCl at 500 and at 750 mosm had no effect on f or on Te or Tpoa. Infusion of NaCl + ACSF at 1,000 mosm reduced f but did not affect Te or Tpoa. In hydrated rabbits, icv infusion of 1,500 mosm NaCl abolished the rise in f and in Te elicited by POA heating at Ta of 25 degrees C. In dehydrated rabbits at 33 degrees C, f was below hydrated levels and icv infusion of water (6.8 microliter/min) produced a reversible elevation in f. These findings suggest that brain osmoreceptors can influence thermoregulation in hot environments.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
I. B. Mekjavic and O. Eiken
Contribution of thermal and nonthermal factors to the regulation of body temperature in humans
J Appl Physiol, June 1, 2006; 100(6): 2065 - 2072.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. Mitono, H. Endoh, K. Okazaki, T. Ichinose, S. Masuki, A. Takamata, and H. Nose
Acute hypoosmolality attenuates the suppression of cutaneous vasodilation with increased exercise intensity
J Appl Physiol, September 1, 2005; 99(3): 902 - 908.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. G. Whyte and A. K. Johnson
Lesions of the anteroventral third ventricle region (AV3V) disrupt cardiovascular responses to an elevation in core temperature
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1783 - R1790.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online