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Am J Physiol Regul Integr Comp Physiol 251: R569-R574, 1986;
0363-6119/86 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 251, Issue 3 569-R574, Copyright © 1986 by American Physiological Society

ARTICLES

Alpha 1-adrenergic receptor activation depolarizes rat supraoptic neurosecretory neurons in vitro

J. C. Randle, C. W. Bourque and L. P. Renaud

Intracellular data were obtained from 35 supraoptic nucleus neurosecretory neurons maintained in vitro in intra-arterially perfused explants of rat hypothalamus. Addition of norepinephrine, phenylephrine, or methoxamine, but not isoproterenol (30-200 microM), consistently induced membrane depolarization, bursting activity, and an associated prolongation in action potential duration, effects that were reversibly antagonized by the alpha 1-antagonist prazosin. Norepinephrine-evoked depolarizations demonstrated no consistent change in membrane resistance and were reduced both by membrane hyperpolarization and by raising extracellular K+. Norepinephrine shortened the time course of spike hyperpolarizing afterpotentials and increased the magnitude of late depolarizing afterpotentials. It is proposed that one of norepinephrine's actions on supraoptic neurons involves K+ channels, perhaps by modulation of a transient K+ current known as A current.


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