AJP - Regulatory, Integrative and Comparative Physiology, Vol 251, Issue 3 481-R491, Copyright © 1986 by American Physiological Society
Anorexia induced in rat by D-glucosamine deoxidized at C-1
K. Fujimoto, T. Sakata, T. Shiraishi, K. Kurata, K. Terada and H. Etou
The effects of D-glucosamine (2-amino-2-deoxy-D-glucose), an endogenous
glucose analogue, and 1-deoxy-D-glucosamine on feeding behavior were
clarified. Test solutions (24 mumol) were infused into the third
cerebroventricle of the rat. Glucosamine induced a feeding episode within
30 min after infusion and then prolonged the ensuing postprandial intermeal
interval for the first 4 h of the dark period, while glucose suppressed
feeding by decreasing meal size. Ventricular injection of
1-deoxyglucosamine potently suppressed feeding in a dose-related manner by
affecting all meal parameters, and oral administration of 2,400 mumol also
induced anorexia. Changes in activity of glucose-sensitive neurons in the
lateral hypothalamus and glucoreceptor neurons in the ventromedial
hypothalamus after electrophoretic application of glucosamine and
1-deoxyglucosamine were compatible with behavior changes. The results
indicate that replacement of a hydroxyl group by an amino group at C-2 of
the glucose molecule affects feeding behavior and deoxidation of C-1
potently induces anorexia.
