AJP - Regulatory, Integrative and Comparative Physiology, Vol 251, Issue 1 187-R191, Copyright © 1986 by American Physiological Society
Renal responses to atriopeptin II are not dependent on renal nerves
J. Krayacich, R. L. Kline, A. Macchi and F. R. Calaresu
The possibility that renal responses to atriopeptin II (AP II) may depend
in part on an inhibition of renal sympathetic nerve effects on the kidney
was investigated in seven anesthetized Wistar rats in which one of the
kidneys was denervated 7-10 days before experimentation. Clearance studies
were done before, during, and after infusion of AP II (0.07 nmol . min-1
iv). During AP II infusion mean arterial pressure (MAP) decreased from 123
+/- 2 to 75 +/- 2 mmHg. Renal blood flow (RBF) was decreased significantly
and renal vascular resistance was increased significantly in the innervated
kidneys but not in the denervated kidneys during AP II infusion. Glomerular
filtration rate during AP II infusion was not significantly altered, but
urine flow rate and the excretion of sodium and potassium were
significantly increased proportionately in both the innervated and
denervated kidneys. These results suggest that 1) the decreased RBF
observed in the innervated kidneys was due to an increase in renal
vasoconstrictor nerve activity reflexly induced by the decrease in MAP
during AP II infusion and 2) renal innervation was not necessary for AP II
to produce a natriuresis and diuresis.
