| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Regulatory, Integrative and Comparative Physiology, Vol 250, Issue 6 1021-R1027, Copyright © 1986 by American Physiological Society
ARTICLES |
D. Burkhoff and K. Sagawa
Based on the recent data from the literature, we derived analytic expressions for ventricular stroke work (SW), ventricular O2 consumption, and the ratio of the former to the latter, defined as ventricular efficiency, in terms of ventricular contractile properties and arterial afterloading properties. The ventricular properties were quantified by Ees and V0, the slope and volume axis intercept, respectively, of the linear end-systolic pressure-volume relationship. Ventricular afterload was represented by the effective arterial elastance (Ea), a parameter that is dependent on aortic input impedance parameters. O2 consumption was assessed by estimating ventricular pressure-volume area, which has been shown to be linearly related to O2 consumption. Model analysis indicated that SW is maximum when Ea = Ees, the afterload that results in the greatest efficiency is always less than that which provides the maximum SW, the SW and efficiency of a weak heart are more sensitive to changes in afterload than in a strong heart, and there is a sigmoidal relation between ventricular efficiency and end-diastolic volume that reaches its maximum at volumes outside the upper limit of the physiological range. Further analysis of the model indicated that under physiological conditions ventricular and arterial properties may be adjusted more toward optimization of efficiency than SW.
This article has been cited by other articles:
|
|
 |
|
  P. D. Chantler, E. G. Lakatta, and S. S. Najjar Arterial-ventricular coupling: mechanistic insights into cardiovascular performance at rest and during exercise J Appl Physiol, October 1, 2008; 105(4): 1342 - 1351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. D. Chantler, V. Melenovsky, S. P. Schulman, G. Gerstenblith, L. C. Becker, L. Ferrucci, J. L. Fleg, E. G. Lakatta, and S. S. Najjar The sex-specific impact of systolic hypertension and systolic blood pressure on arterial-ventricular coupling at rest and during exercise Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H145 - H153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Li, I. S. Ali, and R. W. Currie Insulin-induced myocardial protection in isolated ischemic rat hearts requires p38 MAPK phosphorylation of Hsp27 Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H74 - H87. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Jegger, R. da Silva, X. Jeanrenaud, M. Nasratullah, H. Tevaearai, L. K. von Segesser, P. Segers, V. Gaillard, J. Atkinson, I. Lartaud, et al. Ventricular-arterial coupling in a rat model of reduced arterial compliance provoked by hypervitaminosis D and nicotine Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1942 - H1951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Li, I. S. Ali, and R. W. Currie Insulin induces myocardial protection and Hsp70 localization to plasma membranes in rat hearts Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1709 - H1721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Burkhoff, I. Mirsky, and H. Suga Assessment of systolic and diastolic ventricular properties via pressure-volume analysis: a guide for clinical, translational, and basic researchers Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H501 - H512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Segers, D. Georgakopoulos, M. Afanasyeva, H. C. Champion, D. P. Judge, H. D. Millar, P. Verdonck, D. A. Kass, N. Stergiopulos, and N. Westerhof Conductance catheter-based assessment of arterial input impedance, arterial function, and ventricular-vascular interaction in mice Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1157 - H1164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Wauthy, A. Pagnamenta, F. Vassalli, R. Naeije, and S. Brimioulle Right ventricular adaptation to pulmonary hypertension: an interspecies comparison Am J Physiol Heart Circ Physiol, April 1, 2004; 286(4): H1441 - H1447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Brimioulle, P. Wauthy, P. Ewalenko, B. Rondelet, F. Vermeulen, F. Kerbaul, and R. Naeije Single-beat estimation of right ventricular end-systolic pressure-volume relationship Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1625 - H1630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Tanoue, H. Ando, F. Fukumura, M. Umesue, T. Uchida, K. Taniguchi, and J. Tanaka Ventricular energetics in endoventricular circular patch plasty for dyskinetic anterior left ventricular aneurysm Ann. Thorac. Surg., April 1, 2003; 75(4): 1205 - 1208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Nordhaug, T. Steensrud, C. Korvald, E. Aghajani, and T. Myrmel Preserved myocardial energetics in acute ischemic left ventricular failure - studies in an experimental pig model Eur. J. Cardiothorac. Surg., July 1, 2002; 22(1): 135 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Wronski, E. Seeliger, P. B. Persson, A. Harnath, and B. Flemming Influence of baroreflex on volume elasticity of heart and aorta in the rabbit Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2002; 282(3): R842 - R849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ramanathan, K. Shirota, S. Morita, T. Nishimura, Y. Huang, and S. N. Hunyor Glucose-insulin-potassium solution improves left ventricular mechanics in diabetes Ann. Thorac. Surg., February 1, 2002; 73(2): 582 - 587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Tanoue, A. Sese, Y. Ueno, K. Joh, and T. Hijii Bidirectional Glenn Procedure Improves the Mechanical Efficiency of a Total Cavopulmonary Connection in High-Risk Fontan Candidates Circulation, May 1, 2001; 103(17): 2176 - 2180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. I. P. Trines, C. J. Slager, J. Van der Moer, P. D. Verdouw, and R. Krams Efficiency of energy transfer, but not external work, is maximized in stunned myocardium Am J Physiol Heart Circ Physiol, September 1, 2000; 279(3): H1264 - H1273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Wronski, P. B. Persson, E. Seeliger, A. Harnath, and B. Flemming Coupling of left ventricular and aortic volume elasticity in the rabbit Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2000; 279(2): R539 - R547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Vasan and D. Levy Defining Diastolic Heart Failure : A Call for Standardized Diagnostic Criteria Circulation, May 2, 2000; 101(17): 2118 - 2121. [Full Text] [PDF]
|
|
|
|
|
|
W. H. Devlin, J. Petrusha, K. Briesmiester, D. Montgomery, and M. R. Starling Impact of Vascular Adaptation to Chronic Aortic Regurgitation on Left Ventricular Performance Circulation, March 2, 1999; 99(8): 1027 - 1033. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F Fantini, G Barletta, A Toso, M Baroni, M Di Donato, M Sabatier, and V Dor Effects of reconstructive surgery for left ventricular anterior aneurysm on ventriculoarterial coupling Heart, February 1, 1999; 81(2): 171 - 176. [Abstract] [Full Text]
|
|
|
|
|
|
K. Asai, M. Uechi, N. Sato, W. Shen, T. Meguro, M. A. Mathier, R. P. Shannon, and S. F. Vatner Lack of desensitization and enhanced efficiency of calcium channel promoter in conscious dogs with heart failure Am J Physiol Heart Circ Physiol, December 1, 1998; 275(6): H2219 - H2226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. V. DiPierro, J. E. Bavaria, E. B. Lankford, D. J. Polidori, M. A. Acker, J. T. Streicher, and T. J. Gardner Triiodothyronine Optimizes Sheep Ventriculoarterial Coupling for Work Efficiency Ann. Thorac. Surg., September 1, 1996; 62(3): 662 - 669. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Oe, T. Asou, S. Morita, H. Yasui, and K. Tokunaga PROTAMINE-INDUCED HYPOTENSION IN HEART OPERATIONS: APPLICATION OF THE CONCEPT OF VENTRICULAR-ARTERIAL COUPLING J. Thorac. Cardiovasc. Surg., August 1, 1996; 112(2): 462 - 471. [Abstract] [Full Text]
|
|
|
|
|
|
H. Asanoi, T. Kameyama, S. Ishizaka, T. Nozawa, and H. Inoue Energetically Optimal Left Ventricular Pressure for the Failing Human Heart Circulation, January 1, 1996; 93(1): 67 - 73. [Abstract] [Full Text]
|
|
|
|
|
|
P. Segers, N. Stergiopulos, and N. Westerhof Relation of effective arterial elastance to arterial system properties Am J Physiol Heart Circ Physiol, March 1, 2002; 282(3): H1041 - H1046. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
