AJP - Regulatory, Integrative and Comparative Physiology, Vol 249, Issue 6 747-R752, Copyright © 1985 by American Physiological Society
Renal nerves and initial excretory responses to recumbency: a species comparison
T. V. Peterson, N. L. Hurst and J. A. Richardson
Experiments were performed in anesthetized Macaca fascicularis monkeys and
mongrel dogs to determine if there are species differences concerning the
involvement of the renal nerves in mediating the initial renal effects
occurring with the assumption of recumbency. All animals underwent acute
unilateral renal denervation with the contralateral kidney serving as the
innervated control. Renal perfusion pressure was controlled throughout each
experiment. Control measurements were made with all animals tilted head up
45 degrees, and recumbent measurements were made 5-15 min after the animals
were lowered to 0 degree. In the monkeys, similar increases in urine flow,
absolute and fractional sodium excretion, and creatinine and
p-aminohippurate clearances occurred in both the innervated and denervated
kidneys during recumbency. In contrast, in the dogs, renal denervation
abolished these responses in that increases in these parameters occurred in
the innervated kidneys only. These results demonstrate that the initial
diuresis and natriuresis of recumbency are dependent on the presence of the
renal nerves in the dog but not in the monkey.
