AJP - Regulatory, Integrative and Comparative Physiology, Vol 249, Issue 6 732-R739, Copyright © 1985 by American Physiological Society
Parathyroid transplants and unilateral renal delivery of parathyroid hormone in domestic fowl
R. E. Kissell and R. F. Wideman Jr
Exogenous parathyroid hormone (bovine 1-84 PTH) was infused unilaterally
into the renal portal system or unilaterally into the renal arterial system
of domestic fowl. Endogenous PTH was secreted unilaterally into the renal
portal system by parathyroid tissue transplanted to the leg muscle. None of
the experimental protocols caused significant unilateral phosphaturia,
although unilaterally infused kidneys were shown to have received
significantly more PTH than the contralateral kidneys. The transplanted
parathyroid tissue was a major source of endogenous PTH, as was indicated
by the development of significant hypocalcemia following surgical removal
of the transplant. Unilateral PTH infusion did cause a significant
unilateral increase in sodium excretion and significant bilateral
phosphaturia. These results demonstrate that the phosphaturic and
natriuretic responses to PTH can be dissociated in clearance experiments.
