| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Regulatory, Integrative and Comparative Physiology, Vol 249, Issue 6 643-R666, Copyright © 1985 by American Physiological Society
ARTICLES |
L. Bankir and C. de Rouffignac
It appears difficult to build a coherent picture of the concentrating system of the mammalian renal medulla. This may be due to the diversity of the factors involved and to considerable interspecies differences. Several morphological adaptations that may be critical in the improvement of water conservation are described. They include variations in the length of the papilla, number of nephrons, percentage of long-looped nephrons, nephron heterogeneity, development of pelvic fornices, confluence of collecting ducts, vascular bundles in the inner stripe of the outer medulla, thin descending limb epithelium, and relative development of the three medullary zones. The organization of the medullary circulation is described; the medulla includes several functionally different compartments favoring preferential exchanges by the juxtaposition of certain tubules and vessels. This may improve the efficiency of certain recycling routes and hence the insulation of the different compartments. As discussed in section III, a better inner medullary insulation may be key, not (or not only) in achieving a high urine concentration but mainly in reducing the time required to reach this high concentration. This overview of the multiple interspecies variations in medullary organization underlines the importance, among other factors, of the inner stripe architecture and of the internephron differences in the process of urine concentration.
This article has been cited by other articles:
|
|
 |
|
  H. Dickinson, K. Moritz, E. M. Wintour, D. W. Walker, and M. M. Kett A comparative study of renal function in the desert-adapted spiny mouse and the laboratory-adapted C57BL/6 mouse: response to dietary salt load Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1093 - F1098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-W. Lee, W.-Y. Kim, H.-K. Song, C.-W. Yang, K.-H. Han, H. M. Kwon, and J. Kim Sequential expression of NKCC2, TonEBP, aldose reductase, and urea transporter-A in developing mouse kidney Am J Physiol Renal Physiol, January 1, 2007; 292(1): F269 - F277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, P. J. Flannery, K. Athirakul, S. R. Dunn, W. M. Kourany, and R. F. Spurney G{alpha}q-dependent signaling cascades stimulate water-seeking behavior Am J Physiol Renal Physiol, October 1, 2006; 291(4): F781 - F789. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-W. Lim, K.-H. Han, J.-Y. Jung, W.-Y. Kim, C.-W. Yang, J. M. Sands, M. A. Knepper, K. M. Madsen, and J. Kim Ultrastructural localization of UT-A and UT-B in rat kidneys with different hydration status Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2006; 290(2): R479 - R492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Layton and H. E. Layton A region-based mathematical model of the urine concentrating mechanism in the rat outer medulla. I. Formulation and base-case results Am J Physiol Renal Physiol, December 1, 2005; 289(6): F1346 - F1366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Yang and L. Bankir Urea and urine concentrating ability: new insights from studies in mice Am J Physiol Renal Physiol, May 1, 2005; 288(5): F881 - F896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Bankir, K. Chen, and B. Yang Lack of UT-B in vasa recta and red blood cells prevents urea-induced improvement of urinary concentrating ability Am J Physiol Renal Physiol, January 1, 2004; 286(1): F144 - F151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Pallone, M. R. Turner, A. Edwards, and R. L. Jamison Countercurrent exchange in the renal medulla Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2003; 284(5): R1153 - R1175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Pallone, Z. Zhang, and K. Rhinehart Physiology of the renal medullary microcirculation Am J Physiol Renal Physiol, February 1, 2003; 284(2): F253 - F266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hervy and S. R. Thomas Inner medullary lactate production and urine-concentrating mechanism: a flat medullary model Am J Physiol Renal Physiol, January 1, 2003; 284(1): F65 - F81. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Yang, L. Bankir, A. Gillespie, C. J. Epstein, and A. S. Verkman Urea-selective Concentrating Defect in Transgenic Mice Lacking Urea Transporter UT-B J. Biol. Chem., March 15, 2002; 277(12): 10633 - 10637. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Thomas Inner medullary lactate production and accumulation: a vasa recta model Am J Physiol Renal Physiol, September 1, 2000; 279(3): F468 - F481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Wade, A. J. Lee, J. Liu, C. A. Ecelbarger, C. Mitchell, A. D. Bradford, J. Terris, G.-H. Kim, and M. A. Knepper UT-A2: a 55-kDa urea transporter in thin descending limb whose abundance is regulated by vasopressin Am J Physiol Renal Physiol, January 1, 2000; 278(1): F52 - F62. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Oliverio, M. Delnomdedieu, C. F. Best, P. Li, M. Morris, M. F. Callahan, G. A. Johnson, O. Smithies, and T. M. Coffman Abnormal water metabolism in mice lacking the type 1A receptor for ANG II Am J Physiol Renal Physiol, January 1, 2000; 278(1): F75 - F82. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. VALTIN Carl W. Gottschalk's Contributions to Elucidating the Urinary Concentrating Mechanism J. Am. Soc. Nephrol., March 1, 1999; 10(3): 620 - 627. [Full Text]
|
|
|
|
|
|
S. R. Thomas Cycles and separations in a model of the renal medulla Am J Physiol Renal Physiol, November 1, 1998; 275(5): F671 - F690. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wang, S. R. Thomas, and A. S. Wexler Outer medullary anatomy and the urine concentrating mechanism Am J Physiol Renal Physiol, February 1, 1998; 274(2): F413 - F424. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
