AJP - Regulatory, Integrative and Comparative Physiology, Vol 247, Issue 5 927-R931, Copyright © 1984 by American Physiological Society
Homeostatic capability of rate-sensitive feedback system: mathematical model
M. Okamoto and K. Hayashi
We have predicted the mathematical model of rate-sensitive feedback control
system and have investigated its homeostatic capability by using computer
simulations. The results are summarized as follows. By installing a cyclic
enzyme system as feedback control element, we could assume the
rate-sensitive feedback system at molecular level. This type of feedback
had realistic constant-value control capability for external perturbations.
This feedback system was more effective for the exclusion of perturbation
than was the concentration-sensitive feedback. A large-loop feedback was
more stable for perturbation than was short-loop feedback. In sequential
feedback system, every key enzyme sensitive to feedback control had to vary
the activity at same time for the system to keep homeostasis.
