AJP - Regu AJP: Endocrinology and Metabolism
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 243: R500-R505, 1982;
0363-6119/82 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Morrison, S. F.
Right arrow Articles by Whitehorn, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Morrison, S. F.
Right arrow Articles by Whitehorn, D.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 243, Issue 5 500-R505, Copyright © 1982 by American Physiological Society

ARTICLES

Baroreceptor reflex gain is not diminished in spontaneous hypertension

S. F. Morrison and D. Whitehorn

The magnitudes of both spontaneous and hypothalamically evoked sympathetic nerve activity are greater in spontaneously hypertensive rats (SHR) than in normotensive Wistar-Kyoto rats (WKY). Because the baroreceptor reflex influences the magnitude and time course of the sympathetic response to hypothalamic stimulation, we evaluated the role of the baroreceptor reflex in this sympathetic hyperresponsiveness. Changes in spontaneous nerve activity following comparable shifts in mean blood pressure (static reflex gain) were not different between the two strains. The effect of alterations in prestimulation blood pressure on the size of the evoked sympathetic response (response gain) was greater in SHR. Baroreceptor reflex inhibition resulting from the evoked blood pressure rise during hypothalamic stimulation (dynamic gain) was also greater in SHR. Expressing response magnitudes and gains as a percent of the spontaneous activity eliminated these strain differences. Interruption of the baroreceptor reflex resulted in equivalent percent increases in spontaneous and evoked activity in the two strains. Postdenervation levels of spontaneous and evoked nerve activity were greater in SHR. The results show that sympathetic hyperreactivity in SHR is not due to deficient baroreceptor reflex function.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. C. Salgado, A. R. Barale, J. A. Castania, B. H. Machado, M. W. Chapleau, and R. Fazan Jr.
Baroreflex responses to electrical stimulation of aortic depressor nerve in conscious SHR
Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H593 - H600.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online