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Am J Physiol Regul Integr Comp Physiol 241: R21-R24, 1981;
0363-6119/81 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 241, Issue 1 21-R24, Copyright © 1981 by American Physiological Society

ARTICLES

Dissociation of adrenal corticosteroid production from ACTH in water-restricted female rats

R. G. Doell, M. F. Dallman, R. B. Clayton, G. D. Gray and S. Levine

These experiments were undertaken to investigate the mechanism whereby a precipitous drop in plasma corticosterone concentration is brought about following drinking in rats on a restricted water schedule. No alteration in adrenocorticotrophic hormone (ACTH) output was found, nor was catabolism of corticosterone sufficient to account for the drop. It is concluded that corticosterone level is controlled under these conditions by a mechanism independent of ACTH concentration.


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