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Am J Physiol Regul Integr Comp Physiol 240: R52-R60, 1981;
0363-6119/81 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 240, Issue 1 52-R60, Copyright © 1981 by American Physiological Society

ARTICLES

Intravenous adenosine triphosphate (ATP) in hemorrhagic shock in rats

P. R. Schloerb, L. Sieracki, A. J. Botwin, J. M. Winblad and M. H. Maguire

The effect of intravenous (iv) infusion of 6.25 mumol of ATP-MgCl2 on survival and tissue ATP levels in hemorrhagic shock was investigated using a rat model. Mortality in ATP-MgCl2-treated shocked rats was 50% compared with 53% in saline-treated controls. Tissue ATP levels in ATP-MgCl2-treated shocked rats did not differ from those in saline-treated shocked rats nor from those in sham-operated controls. After iv infusion of 6.25 mumol of [8-14C]ATP-MgCl2, shocked, sham-operated, and nephrectomized rats had similar tissue distributions of 14C. The 14C in heart, lung, kidney, and liver of shocked and sham-operated rats was present almost entirely as nonphosphorylated [8-14C]ATP catabolites. It is concluded that ATP-MgCl2 iv did not benefit survival or enhance tissue ATP levels in shocked animals and that the administered ATP was rapidly and extensively degraded.




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