AJP - Regulatory, Integrative and Comparative Physiology, Vol 239, Issue 3 277-R284, Copyright © 1980 by American Physiological Society
Effects of pressure on cerebrospinal fluid formation: nonsteady-state measurements in dogs
F. H. Sklar, J. Reisch, I. Elashvili, T. Smith and D. M. Long
Effects of pressure on cerebrospinal fluid (CSF) formation were studied in
dogs with a recirculatory spinal perfusion tracer clearance technique that
does not require steady-state conditions. The data permit statistical
analysis of the relationship between the rate of CSF formation and pressure
for individual animals. Most animals showed no statistical relationship
between CSF formation and intracranial pressure (ICP) and/or cerebral
perfusion pressure (CPP). In this study, a disturbance of cerebral blood
flow (CBF) autoregulation may have been present in five animals on the
basis of CPP reductions, and four of this latter group showed formation to
decrease with increasing ICP. It is suggested that CSF formation is
normally pressure insensitive. With impaired autoregulation of CBF,
formation may follow CBF and CPP passively.
