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Am J Physiol Regul Integr Comp Physiol 238: R432-R437, 1980;
0363-6119/80 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 238, Issue 5 432-R437, Copyright © 1980 by American Physiological Society

ARTICLES

Postnatal development of the renin-angiotensin system in rats

K. B. Wallace, J. B. Hook and M. D. Bailie

The purpose of this investigation was to correlate the development of the various enzyme activities associated with the renin-angiotensin system with age-related differences in the steady-state concentrations of angiotensin I (AI) and II (AII). Angiotensin was quantified by radioimmunoassay. Plasma renin activity and concentration increased between birth and 3 wk of age, and declined thereafter to adult values. Renal renin content, on the other hand, increased throughout the first 6 wk of postnatal life. The concentration of AII in plasma also increased following birth; however, maximum concentrations were not attained until 5 wk of age. In contrast, plasma AI did not increase between 3 and 6 wk of age. These data suggest that the steady-state concentration of AII in neonatal rat plasma may be partially limited by the low plasma renin substrate concentration. The increase in AII between 3 and 6 wk of age may reflect the increasing converting enzyme activity.


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