AJP - Regulatory, Integrative and Comparative Physiology, Vol 236, Issue 5 297-R301, Copyright © 1979 by American Physiological Society
Renal function in Lophius americanus: effects of angiotensin II
P. C. Churchill, R. L. Malvin, M. C. Churchill and F. D. McDonald
Arterial blood pressure, urine flow rate, and plasma and urine electrolytes
were measured in the aglomerular goosefish (L. americanus) before, during,
and after the intravenous infusion of angiotensin II (from 5 to 280
ng/min.kg body wt). Increases in arterial blood pressure were directly
related to the logarithm of the angiotensin infusion rate (r = 0.62, P less
than 0.005). Angiotensin also increased urine flow from 0.676 +/- 0.065 to
0.755 +/- 0.068 ml/h.kg body wt (P less than 0.005) and Na excretion from
41.0 +/- 5.5 to 54.4 +/- 7.0 mumol/h.kg body wt (P less than 0.001). In 17
of the 19 fish infused with angiotensin the diuretic and natriuretic
effects were directly related to the logarithm of the infusion rate (r =
0.44, P less than 0.04 and r = 0.51, P less than 0.02, respectively). There
was no relationship between the pressor and the diuretic or natriuretic
effects of angiotensin II. These results are consistent with inhibitory
effects of angiotensin on solute transport by aglomerular tubules.
