AJP - Regulatory, Integrative and Comparative Physiology, Vol 236, Issue 5 254-R260, Copyright © 1979 by American Physiological Society

ARTICLES

Calories and gastric emptying: a regulatory capacity with implications for feeding

P. R. McHugh and T. H. Moran

Gastric emptying in four unanesthetized male Macaca mulatta was studied with the serial test meal method of Hunt and Spurrell. Liquid meals were infused into the stomach through a chronic indwelling Silastic cannula. Saline meals empty rapidly and exponentially. Doubling the volume of saline from 150 to 300 ml increased the emptying rate so that the half-life remained unchanged (15 min). The 150-ml glucose meals (0.05, 0.125, and 0.25 g/ml) emptied more slowly than saline, progressively more slowly with increasing concentrations (0.05--1.8, 0.125--0.78, and 0.25--0.37 ml/min) and linearly through most of their course. Doubling the volume of 0.125 g/ml-glucose meal did not change the rate of emptying. Converting grams of glucose to their caloric content, the emptying rate in kcal/min becomes constant (approx 0.4 kcal/min) in this range of concentrations. Isocaloric casein hydrolysate and medium-chain triglyceride oil meals at 0.5 kcal/ml empty at the same rate as glucose. The precision of this regulation is sufficient to give it a role in preabsorptive satiety and the control of caloric intake.

This article has been cited by other articles:

				S. Gonlachanvit, R. Coleski, C. Owyang, and W. L. Hasler Nutrient modulation of intestinal gas dynamics in healthy humans: dependence on caloric content and meal consistency. Am J Physiol Gastrointest Liver Physiol, September 1, 2006; 291(3): G389 - G395. [Abstract] [Full Text] [PDF]

				K. L. Jones, D. O'Donovan, A. Russo, J. H. Meyer, J. E. Stevens, Y. Lei, J. Keogh, A. Tonkin, and M. Horowitz Effects of drink volume and glucose load on gastric emptying and postprandial blood pressure in healthy older subjects Am J Physiol Gastrointest Liver Physiol, August 1, 2005; 289(2): G240 - G248. [Abstract] [Full Text] [PDF]

				T. H. Moran, U. Smedh, K. P. Kinzig, K. A. Scott, S. Knipp, and E. E. Ladenheim Peptide YY(3-36) inhibits gastric emptying and produces acute reductions in food intake in rhesus monkeys Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2005; 288(2): R384 - R388. [Abstract] [Full Text] [PDF]

				M. R. Hayes, R. L. Moore, S. M. Shah, and M. Covasa 5-HT3 receptors participate in CCK-induced suppression of food intake by delaying gastric emptying Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2004; 287(4): R817 - R823. [Abstract] [Full Text] [PDF]

				U. Smedh and T. H. Moran Peptides that Regulate Food Intake: Separable mechanisms for dorsal hindbrain CART peptide to inhibit gastric emptying and food intake Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1418 - R1426. [Abstract] [Full Text] [PDF]