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Am J Physiol Regul Integr Comp Physiol 236: R75-R82, 1979;
0363-6119/79 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 236, Issue 1 75-R82, Copyright © 1979 by American Physiological Society

ARTICLES

Osmosensitivity of rat third ventricle and interactions with angiotensin

J. Buggy, W. E. Hoffman, M. I. Phillips, A. E. Fisher and A. K. Johnson

Injections of hyperosmotic solutions (1- to 5-microliter injections of NaCl or sucrose solutions ranging in osmolarity from 0.34 to 0.90 osmol/l) into the anteroventral third ventricle (AV3V) of rats resulted in short latency drinking antidiuretic, and pressor responses. AV3V injections or infusions of combined angiotensin-hyperosmotic NaCl solution did not result in drinking greater than the sum of drinking to angiotensin and hyperosmotic NaCl separately administered. Differences in water versus saline drinking fluid preferences provided a behavioral dissociation of angiotensin and hyperosmotic sensitive neural mechanisms. Comparison of AV3V and lateral preoptic injection sites provided an additional separation since angiotensin was equally effective at both sites whereas osmotic stimulation was more effective at the AV3V site. AV3V lesions have previously been reported to abolish drinking, antidiuretic, and pressor responses to angiotensin and hyperosmotic stimulation. The data reported here provide additional evidence that angiotensin and hyperosmotic stimuli may both act on tissue surrounding AV3V but suggest that the neural substrates for these stimuli are not identical.


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R. F. Johnson, T. G. Beltz, R. L. Thunhorst, and A. K. Johnson
Investigations on the physiological controls of water and saline intake in C57BL/6 mice
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2003; 285(2): R394 - R403.
[Abstract] [Full Text] [PDF]


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