AJP - Regulatory, Integrative and Comparative Physiology, Vol 236, Issue 1 21-R30, Copyright © 1979 by American Physiological Society
Metabolism of the acutely ischemic dog heart. I. Construction of a computer model
M. J. Achs and D. Garfinkel
Construction of a computer model of glycolysis, the Krebs cycle, and
related metabolism in acutely ischemic dog heart, involving 122
metabolites, 65 enzymes, and 406 chemical reactions, is described. A
previous model of the same metabolism in normal-flow rat heart was modified
to fit ischemic dog heart experimental data to within experimental error.
The result resembles other models of ischemic heart preparations, implying
common underlying mechanisms. The principal change made was reduction of
enzyme amounts, consistent with the generally slower metabolism of large
animals, suggesting that differing enzyme amounts are a major component of
interspecies metabolic difference. Glycolytic intermediates oscillate,
asynchronously and with large changes in level; pyridine nucleotides become
highly reduced; pH falls, but mitochondria stay alkaline relative to
cytoplasm even after oxidative phosphorylation stops.
