AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 233: R1-R7, 1977;
0363-6119/77 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Feldman, H. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Feldman, H. A.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 233, Issue 1 1-R7, Copyright © 1977 by American Physiological Society

ARTICLES

A numerical method for fitting compartmental models directly to tracer data

H. A. Feldman

A numerical method is presented for obtaining the exchange rates of a metabolic compartmental system, working directly from the time course of tracer activity and excretion after bolus injection. The conventional mathematical formulation of this problem, in terms of sums of exponential functions, is bypassed, enabling implementation of the method in a short computer program. An important by-product of the method is a set of variance-covariance estimates for the fitted parameters. The method is tested on "classic" data, both simulated and real. Its capabilities and limitations are demonstrated, and the strategy of its effective application is discussed.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online